Travelling by bus to the Royal Botanic Garden is a breeze! In addition to the stops at nearby Martin Place and Circular Quay, the 441 route (Balmain via QVB Building) leaves York Street, Town Hall on weekdays, 10 am - 5 pm and stops outside the Art Gallery of NSW.
The 200 route (Chatswood to Bondi) stops in Macquarie Street during peak hours on weekday mornings and evenings.
The Sydney Explorer Bus also includes the Domain on its route.